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Gravatar #51 - dugfrisk
5. maj 2023 03:43
Gravatar #52 - dugfrisk
5. maj 2023 04:38
rettidig omhu
Gravatar #59 - dugfrisk
3. jun. 2023 11:42
Cyclophilin (Cyp) proteins play an important role during the lifecycle of viruses from different families, such as hepatitis C virus, human immunodeficiency virus, dengue virus, human papillomavirus, cytomegalovirus, influenza A virus, vesicular stomatitis virus, Japanese encephalitis virus, and various CoVs. The lifecycles of NL-63 (HCoV-NL63), human CoV 229 E (HCoV-229 E), and SARS-CoV that causes mild respiratory infections in humans, as well as feline infectious peritonitis coronavirus (FPIV) that causes fatal disease in cats, is reported to be dependent on CypA, which plays an important role in CoV replication. Cyclosporine A (CsA), which is the inhibitor of CypA can provide a broad-spectrum suppression of CoV.

The 18 kDa human cyclophilin A (hCypA) belongs to the immunophilin family and is both present and conserved in prokaryotes and eukaryotes. The hCypA protein consists of peptidyl-prolyl cis-trans isomerase (PPIase) activity and can carry out the catalysis of cis-trans isomerization of peptide bonds at proline residues as well as regulate protein trafficking

https://www.news-medical.net/news/20221102/What-is...

https://www.news-medical.net/?tag=/Cyclosporine
Gravatar #64 - dugfrisk
i dag 07:43
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